Cell Culture Scientist

You will join a scientific team, where you will have responsibility for the generation of new cell lines producing recombinant proteins according to agreed timelines.  You will contribute to the  process optimisation and development of existing cell lines and you will be responsible for writing and maintaining Standard Operating Procedures, ensuring regulatory and safety compliance at all times.

Applicants should possess a PhD in a relevant area and have extensive experience in mammalian cell culture, process development and protein analysis. You  will have experience in writing and reviewing protocols and knowledge of cGMP operations.

Duties

Duties and responsibilities include, but are not limited to:

• Design and execution of experiments to optimize production of recombinant protein in cell cultures
• Establishment, maintenance and scale up of mammalian cell cultures to bioreactors
• Development of assays and analytical procedures relating to the integrity of the recombinant proteins produced in cell culture
• Development and writing of standard operating procedures and maintaining records of activities in the facility to GLP standards.

 Reporting Relationships

The position reports to the Chief Executive Officer

Selection Criteria

Qualifications

Essential

• A PhD in a relevant area and
• Extensive experience in recombinant mammalian cell line development.

Knowledge and Skills
Essential

• Demonstrated expert knowledge in the area of recombinant protein production
• demonstrated expert knowledge in cellular transfections, selection/amplification, single cell isolation, cell culture maintenance and protein analysis,
• Knowledge and experience in scale-up operations.
• Knowledge of GMP operations as they apply to recombinant protein production

Desirable

• Experience in the field of monoclonal antibody technology

Applications must consist of the following:

• Covering Letter.  The covering letter should include, your contact address and telephone number.  It is an opportunity in not more than one page to introduce yourself and highlight the key reasons you should be considered for the role.
• Resume.  Give is a brief history of your employment and experience that covers the following areas:
• Educational qualifications and professional affiliations that detail the full title of the qualification, the year awarded and the title of the institution attended;
• Employment history in chronological order, starting with current position and specifying dates of employment, title of each position, name of employer, main duties or accountabilities and achievements; and
• The names and contact details (address, telephone, fax and e-mail) of three referees, including if possible a senior person (preferably your supervisor or the head of your organisational unit) closely associated with your current work.
• Selection Criteria.  Please submit a statement addressing how each of the selection criteria (see above)  have been met.

The successful applicant will be rewarded with a competitive remuneration package, including incentive arrangements, commensurate with experience.